Performance assessment & synergic operation of algorithmic solutions enabling opportunistic networks– D4.2

Deliverable D4.2 del projecte europeu OneFITPeer ReviewedPostprint (updated version

Validation platform implementation description – D5.2

Deliverable D5.2 del projecte OneFITPostprint (published version

Business scenarios, technical challenges and system requirements - D2.1

Deliverable D2.1 del projecte Europeu OneFIT (ICT-2009-257385)Preprin

Results analysis and validation - D5.3

Deliverable D5.3 del projecte OneFITPostprint (author’s final draft

Performance evaluation of synergic operation of algorithms enabling opportunistic networks - D4.3

Deliverable D4.3 del projecte OneFITPreprin

Validation platform specification – D5.1

Deliverable D5.1 del projecte Europeu OneFIT (ICT-2009-257385)The present deliverable introduces the OneFIT Proof-of-Concept (PoC) Architecture which will be used as a basis for the validation platform development throughout the project. This PoC Architecture proposal is validated by identifying the roles of the various components in the framework of the OneFIT Scenarios as derived and detailed in WP2. The applied methodology ensures that all required features are appropriately considered. Furthermore, the hardware components available to the project are detailed which are the basis for the development of an integrated validation platform. Their role is highlighted by an instantiation step which maps the PoC Architecture components to the identified hardware components. Finally, a scenario instantiation is derived which illustrates the role of the various hardware components for the validation of selected OneFIT scenarios.Postprint (published version

OneFIT functional and system architecture - D2.2

Deliverable D2.2 del projecte Europeu OneFIT (ICT-2009-257385)This document presents the OneFIT functional and system architecture for the management and control of infrastructure coordinated opportunistic networks (ONs). The most relevant building blocks "Cognitive management System for the Coordination of the Infrastructure" (CSCI) and the "Cognitive Management system for the Opportunistic Network" (CMON) are described.Postprint (published version

Catheter-Based Renal Sympathetic Denervation for Resistant Hypertension Durability of Blood Pressure Reduction Out to 24 Months

Renal sympathetic hyperactivity is seminal in the maintenance and progression of hypertension. Catheter-based renal sympathetic denervation has been shown to significantly reduce blood pressure (BP) in patients with hypertension. Durability of effect beyond 1 year using this novel technique has never been reported. A cohort of 45 patients with resistant hypertension (systolic BP GT = 160 mm Hg on GT = 3 antihypertension drugs, including a diuretic) has been originally published. Herein, we report longer-term follow-up data on these and a larger group of similar patients subsequently treated with catheter-based renal denervation in a nonrandomized manner. We treated 153 patients with catheter-based renal sympathetic denervation at 19 centers in Australia, Europe, and the United States. Mean age was 57 +/- 11 years, 39% were women, 31% were diabetic, and 22% had coronary artery disease. Baseline values included mean office BP of 176/98 +/- 17/15 mm Hg, mean of 5 antihypertension medications, and an estimated glomerular filtration rate of 83 +/- 20 mL/min per 1.73 m(2). The median time from first to last radiofrequency energy ablation was 38 minutes. The procedure was without complication in 97% of patients (149 of 153). The 4 acute procedural complications included 3 groin pseudoaneurysms and 1 renal artery dissection, all managed without further sequelae. Postprocedure office BPs were reduced by 20/10, 24/11, 25/11, 23/11, 26/14, and 32/14 mm Hg at 1, 3, 6, 12, 18, and 24 months, respectively. In conclusion, in patients with resistant hypertension, catheter-based renal sympathetic denervation results in a substantial reduction in BP sustained out to GT = 2 years of follow-up, without significant adverse events. (Hypertension. 2011;57:911-917.